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Canadian surgeon Dr. Norman Bethune (Donald Sutherland) journeys 1,500 miles into China to reach Mao Zedong's eighth route Army in the Wu Tai mountains where he will build hospitals, provide care, and train medics. Flashbacks narrate the earlier events of his life: a bout with tuberculosis at the Trudeau sanatorium; the self-administration of an experimental pneumothorax; the invention of operative instruments; his fascination with Socialism; a journey into medical Russia; and the founding of a mobile plasma-transfusion unit in war-torn Spain. Bethune twice married and twice divorced his wife Frances (Dame Helen Mirren), who chooses abortion over child-rearing in her unstable marriage. By 1939, Bethune had been dismissed from his Montreal Hospital for taking unconventional risks, and from his volunteer position in Spain for his chronic problems of drinking and womanizing. As his friend states: "China was all that was left." Even there, Bethune confidently ignores the advice of Chinese officials until heavy casualties make him realize his mistake and lead him to a spectacular apology.

田上是一位英俊潇洒、风流倜傥的成功创业者，有一天他突然发现自己那“男人的尊严”不见了！更要命的是，他必须在6天内找回来，否则就将永远变“太监”，于是他急切地踏上了“寻根”之旅。曾以《摄影机不要停》创下日本电影界以小搏大票房奇迹的鬼才导演上田慎一郎在这部新作中再次大开脑洞、剑走偏锋，为观众带来一部无厘头风格的鬼马狂想曲。看似荒诞无稽的“寻根”之旅，实际亦是找回初心的成长过程，让观众在捧腹爆笑之余，更能感受到那一丝泪目温情。

比尔梦想自己有所作为，无论是通过运送货物还是饲养贵宾犬，他都决心通过努力实现“美国梦”。和他一条街区的马特奥则迫不及待地想成为一个男人。由于渴望得到年轻父亲的认可，一系列冲动的决定使马特奥的生活发生了变化，他发现自己还没有能力应对成人世界的残酷现实。

解放战争时期，粤北游击队驻地。叶永茂（中叔皇 饰）受上级委派只身赴马龙（郭振清 饰）所控杂牌武装，动员他们起义，接受共产党收编。收编后命名为“独立大队”，但马对叶及游击队始终怀有戒心，加之拜把兄弟刁飞虎（庞学勤 饰）从中作梗，更是对革命三心二意。一次去村里执行任务，刁竟与地主婆勾搭在一起，牛牯（达奇 饰）见状愤然离队，刁反诬牛牯携枪叛逃，牛牯当众揭发刁的土匪行径引众怒，纷纷要求严惩，但马念刁曾经的救命之思而手下留情。李登高（孙笑非 饰）叛变后，唆使刁用调虎离山计引马率部接应敌人的起义部队，马不知是计，险遭毒手，幸亏叶永茂及时赶到挽救了独立大队，严酷的现实擦亮了马龙的眼睛......