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故事以世界末日即将来临的2012年为故事背景，无业青年吴安良，找来死党郝歌，以及语言不同却心灵相通的异国美女阿代儿，从旧约圣经诺亚方舟的故事获得灵感，号召在网络上打造一艘名为「卡拉图号」的虚拟方舟，企图让全世界七十亿人透过社群网络结为「亲人」，用爱与和平，携手度过人类文明的毁灭危机。但他们却遭到神秘组织绑架，囚禁在宛如精神病院的地下基地…

卫斯理（刘德华）是联合国外星生物分析局的特别成员，负责处理地球上一切和外星生物有关的事件。某次在古董店参观一块奇异的蓝色“人骨”时，卫斯理遇到少时曾有过一面之缘的、外表看来和一般美女无异的、血液是蓝色的外星人方天涯（关芝琳），当他想将其留住时，方天涯消失了。古董店附近 发生了一宗外星生物突袭事件，美国隶属FBI的外星生物调查机构接到上级命令，派出队中精英白素（舒淇）和白奇伟（张耀扬）兄妹领队到现场调查，众人与具有A级战斗力的外星生物展开交战。闻得风声的卫斯理也前来助阵，无奈不敌强大的敌手身受重伤，方天涯及时现身以奇异力量救出卫斯理，两人就此开始一段离奇情缘。

When novelist Hyun-soo moves to a new place, he is suddenly visited by a strange woman who says that she used to live there. Hyun-soo and Jeong-yoon discuss a movie Jeong-yoon plans to make, but this results in them breaking up and say their goodbyes. A stranger named Yoon-joo tells Hyun-soo a secret about his dead wife So-young, and he decides to go explore her past. Novelist Jeong-yoon goes to meet Yoon-joo, the person she based her novel on, in order to finish some business. They are all wandering, in her memories, in his novel and in their movies...

人的记忆都存在大脑的海马回里，而“海马洗头店”可以让你有选择性的，把快乐或悲伤的记忆刷洗干净……