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恶毒的不动产从业者吴某因为再开发事业而急匆匆地在山路上驾驶，中途遭遇事故，被山中一偏僻住所的张某所救，张某一家的亲切和善背后似乎藏着什么不为人知的秘密，当吴某得知自己过去的恶行与张某一家的关系时，生命受到威胁…

建安五年(公元200年)，曹操与袁绍准备决战于官渡时，突然头痛发作，神医华陀仅为曹操扎了一针便治好了他的病。曹操想将华陀留于军中为自己治病，华陀却想用医术造福于天下疾苦百姓，并研制出麻药，退辞离开。后曹操又发出委任状，使华陀不得不随军任职。华陀偶然发现曹操四子曹冲患有致命隐疾，便写下治疗的药方给曹丕，但曹丕为争权位，将药方烧了。华陀接到妻子云卿讲述发现麻药线索的信，告假连夜返家。但当华陀努力寻找麻药时，爱子沸儿因误服野果中毒身亡，华陀夫妇悲痛万分，将研制成的麻药命名为“麻沸散”。曹操派人将华陀强行押回军营，又因他晚到而将他关入牢房。后曹操为防止华陀奉诏入宫为伏后治病，命人监斩华陀。华陀愤而烧毁刚刚写就的医术“麻沸散”并预言曹操将自食其果。后曹冲隐疾突发，曹操欲收回斩华陀的命令却为时已晚。曹操痛悔不已。

故事发生在上个世纪70年代英国统治下的香港，万天鹰因为有英国人做靠山，横行霸道逼良为娼，铁记饭店老板娘铁姐（徐冬冬饰）带领手下员工小豹子（谢苗饰）等人对峙恶势力，为老公复仇，最终还香港和平与安宁

Darkside Blues (Japanese: ダークサイド・ブルース, Hepburn: Dākusaido Burūsu) is a manga series by Hideyuki Kikuchi. The story has been adapted into an anime film directed by Yoshimichi Furukawa. The film was originally licensed by Central Park Media and then later licensed by ADV Films.The story involves the town of Kabuki-cho, home of a resistance faction called Messiah. In the futuristic setting, Kabuki-cho is one of the last places of freedom because the Persona Century Corporation has taken control of the majority of the Earth. Kabuki-cho is hence known as "The Dark Side of Tokyo". Furthermore, a mysterious stranger called Darkside appears to protect the citizens of Kabuki-cho.