Eun-gi's eventful life in a boarding house has begun with the three ladies: a sexy owner of a boarding house, her daughter who is even sexier, and his innocent first love. Eun-gi, a freshman, has found his new place in a boarding house operated by mother and daughter when he came to Seoul to study. His only pleasure is to play along in the unspoken push-and-pull relationship with the mother or the daughter. One day, his first love, Soon-yi, who is innocent and docile, suddenly comes to visit him at the boarding house. With the sexy daughter of the boarding house behind the door, and the curvaceous lady owner of the boarding house in the bathroom next to his room, the 20-year-old virgin Eun-gi's sleepless night begins.

查小刀（孙俪 饰）智商极高，但性格软弱怕事，莫非里（邓超 饰）不过是一介混混，但个性嚣张跋扈，一场车祸让两人相遇，莫非里毫无意外的狠狠在查小刀的身上诈了一笔。亲情淡漠，工作受挫，又遭恶人欺压，查小刀心灰意冷，无意之中得知了有一位名为折耳根（梁超 饰）的神医专治各种疑难杂症，于是便起了向他寻求良方的念头。让查小刀没有想到的是，莫非里居然也是折耳根的病人，常年的失眠困扰着他令他痛不欲生。折耳根告诉两人，他们其实正是彼此的“良药”，为了“治病”，查小刀和莫非里结为搭档共同进退，惹出了无数的麻烦和笑话，与此同时，亦结下了深厚的感情。

故事讲述三个年轻人去当地医生家里进行偷窃，意想不到的是，医生提前回到了家中。

十年前，三流小说家中田修一（清水紘治 饰）怀疑妻子和出版界的好友津野木有染，这件事令他耿耿于怀，夫妻的关系也日趋冷淡。随后的五年里，津野木在出版界风生水起，而中田的妻子却不幸死于一场意外。在此之后，中田将自己的经历写成一本情色小说，从而变得小有名气，而他也选择堕落放荡的生活。原本羞涩内向的他，早已是情人多多的风流男子。情人中有著名的花道老师，有痴迷其作品的读者香枝，也有特立独行的女同性恋麦姬。繁花似锦终有时，喧嚣过后只留下无限的失落和怅然……本片根据吉行淳之介的原著改编，为日活成立七十周年的纪念作品。